TABLE

A downloadable version is available and full details of the process used to create this table can be found in the methodology section.
Symbol Description GeneID Chr Chr Band Tumour Types Supporting evidence Class Only gene within minimal amplification region Tumour Status in Cancer Gene Census if not just amplicon KEGG Pathways
JUNJUN oncogene372511p32-p31SarcomaOEIII*MAPK signaling pathway, ErbB signaling pathway, Wnt signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, GnRH signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Colorectal cancer, Renal cell carcinoma
MYCL1MYC homolog461011p34.2LungDC, FM, KBII*
ALC1/CHD1Lhelicase DNA binding protein955711q12Hepatocellular carcinomaOB, KBIII
SHCA/SHC1Src homology domain containing646411q21BreastSPIIIErbB signaling pathway, Focal adhesion, Natural killer cell mediated cytotoxicity, Insulin signaling pathway, Glioma, Chronic myeloid leukemia
CKS1/CKS1BCDC28 regulatory subunit116311q21.2BreastDC, EC, KB, OBIIISmall cell lung cancer
RAB25RAS oncogene family5711111q22OvarianDC, EC, SP, KB, OBII
CACNA1Ecalcium channel protein77711q25-q31Wilms' tumourDC, ECIII*MAPK signaling pathway, Calcium signaling pathway, Type II diabetes mellitus
MDM4p53 binding protein419411q32RetinoblastomaSP, MS, DIIIp53 signaling pathway
MDM4p53 binding protein419411q32GliomaSPIIIp53 signaling pathway
AKT3v-akt murine thymoma viral oncogene homolog 31000011q43-q44GliomaSPIIIMAPK signaling pathway, ErbB signaling pathway, Chemokine signaling pathway, mTOR signaling pathway, Apoptosis, VEGF signaling pathway, Focal adhesion, Tight junction, Toll-like receptor signaling pathway, Jak-STAT signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Neurotrophin signaling pathway, Insulin signaling pathway, Pathways in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer
RELviral oncogene homolog596622p13-p12Diffuse large B cell lymphomaSPIII
RELviral oncogene homolog596622p13-p12Hodgkin's lymphomaSPIIIc
MYCNMYC homolog461322p24.1NeuroblastomaDC, EC, KB, OB, OEII*
MYCNMYC homolog461322p24.1RhabdomyosarcomaDC, ECIII
MYCNMYC homolog461322p24.1LungFMIII
YWHAQtryptophan monooxygenase activation protein1097122p25.1BladderSPIIICell cycle, Pathogenic Escherichia coli infection - EHEC, Pathogenic Escherichia coli infection - EPEC
MITFmicrophthalmia-associated transcription factor428633p14.2-p14.1Malignant melanomaEC, OBIIIMelanogenesis, Melanoma
RUVBL1RuvB-like 1 (E. coli)860733q21BreastSPIIIWnt signaling pathway
eIF-A2/EIF5A2eukaryotic translation initiation factor 5A25664833q26.2OvarianEC, KBIII
PIK3CAphosphoinositide-3-kinase alpha polypeptide529033q26.3OvarianDC, MX, SP, DIIIMisInositol phosphate metabolism, ErbB signaling pathway, Phosphatidylinositol signaling system, mTOR signaling pathway, Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Insulin signaling pathway, Type II diabetes mellitus, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer
SCCRO/DCUN1D1DCN1, defective in cullin neddylation 1, domain containing 15416533q26.3LungECIII
SCCRO/DCUN1D1DCN1, defective in cullin neddylation 1, domain containing 15416533q26.3Head and neckECIII
PRKCIprotein kinase C, iota558433q26.3OesophagealECIIITight junction, Insulin signaling pathway
ZASC1/ZNF639zinc finger protein 6395119333q26.32OesophagealEC, KB, OBIII
KITsarcoma viral oncogene homolog381544q11-q12Testicular germ cell tumourMXIII*Mis, OCytokine-cytokine receptor interaction, Hematopoietic cell lineage, Melanogenesis, Acute myeloid leukemia
SKP2S-phase kinase-associated protein 2 (p45)650255p13LungEC, SP, KBIICell cycle, Ubiquitin mediated proteolysis, Small cell lung cancer
SKP2S-phase kinase-associated protein 2 (p45)650255p13OesophagealDG, EC, KB, OBIIICell cycle, Ubiquitin mediated proteolysis, Small cell lung cancer
SKP2S-phase kinase-associated protein 2 (p45)650255p13Soft tissue sarcomaECIIICell cycle, Ubiquitin mediated proteolysis, Small cell lung cancer
RAB23RAB23, member RAS oncogene family5171566p11GastricKBIIIHedgehog signaling pathway
E2F3E2F transcription factor 3187166p22BladderEC, SP, KBIIICell cycle, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer
E2F3E2F transcription factor 3187166p22RetinoblastomaSPIIICell cycle, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer
MAP3K5protein kinase kinase kinase 5421766q22.33SarcomaOEIIIMAPK signaling pathway
EGFRepidermal growth factor receptor195677p12GliomaFM, SP, OBIIIO, MisMAPK signaling pathway, ErbB signaling pathway, Calcium signaling pathway, Cytokine-cytokine receptor interaction, Focal adhesion, Adherens junction, Gap junction, Regulation of actin cytoskeleton, GnRH signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer
EGFRepidermal growth factor receptor195677p12LungFMIIIO, MisMAPK signaling pathway, ErbB signaling pathway, Calcium signaling pathway, Cytokine-cytokine receptor interaction, Focal adhesion, Adherens junction, Gap junction, Regulation of actin cytoskeleton, GnRH signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer
EGFRepidermal growth factor receptor195677p12OesophagealEC, FMIIIO, MisMAPK signaling pathway, ErbB signaling pathway, Calcium signaling pathway, Cytokine-cytokine receptor interaction, Focal adhesion, Adherens junction, Gap junction, Regulation of actin cytoskeleton, GnRH signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer
EGFRepidermal growth factor receptor195677p12ColorectalSP, DMIO, MisMAPK signaling pathway, ErbB signaling pathway, Calcium signaling pathway, Cytokine-cytokine receptor interaction, Focal adhesion, Adherens junction, Gap junction, Regulation of actin cytoskeleton, GnRH signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer
MDS/ETV1ets variant gene 1211577p21.3OvarianDC, EC, KBIII
CDK6cyclin-dependent kinase 6102177q21-q22GliomaSPIIITCell cycle, p53 signaling pathway, Pathways in cancer, Pancreatic cancer, Glioma, Melanoma, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer
ARPC1/ARPC1Aactin related protein 2/3 complex1055277q22.1PancreaticKBIIIRegulation of actin cytoskeleton
SMURF1E3 ubiquitin protein ligase 15715477q22.1PancreaticKB, SPIIIUbiquitin mediated proteolysis, TGF-beta signaling pathway
METhepatocyte growth factor receptor423377q31GastricDC, KB, DI, SPIIIMisCytokine-cytokine receptor interaction, Axon guidance, Focal adhesion, Adherens junction, Epithelial cell signaling in Helicobacter pylori infection, Colorectal cancer, Renal cell carcinoma, Melanoma
METhepatocyte growth factor receptor423377q31LungKB, SPIIIMisCytokine-cytokine receptor interaction, Axon guidance, Focal adhesion, Adherens junction, Epithelial cell signaling in Helicobacter pylori infection, Colorectal cancer, Renal cell carcinoma, Melanoma
METhepatocyte growth factor receptor423377q31GliomaSPIIIMisCytokine-cytokine receptor interaction, Endocytosis, Axon guidance, Focal adhesion, Adherens junction, Epithelial cell signaling in Helicobacter pylori infection, Pathways in cancer, Colorectal cancer, Renal cell carcinoma, Melanoma
SHHsonic hedgehog646977q36OesophagealDIIIIHedgehog signaling pathway, Basal cell carcinoma
C8orf4chromosome 8 open reading frame 45689288p11.2BreastOBIII
LSM1U6 small nuclear RNA associated2725788p11.2BreastDC, KB, OBIII
LSM1U6 small nuclear RNA associated2725788p11.2BreastOBIII
WHSC1L1Wolf-Hirschhorn syndrome candidate like5490488p11.2LungKBIIIT
FGFR1fibroblast growth factor receptor 1226088p11.2-p11.1RhabdomyosarcomaSPIIITMAPK signaling pathway, Adherens junction, Regulation of actin cytoskeleton, Prostate cancer, Melanoma
FGFR1fibroblast growth factor receptor 1226088p11.2-p11.1BreastKB, DI, SPIIITMAPK signaling pathway, Adherens junction, Regulation of actin cytoskeleton, Prostate cancer, Melanoma
BAG4BCL2-associated athanogene 4953088p12BreastOB, SPIII
MTDHmetadherin9214088q22.1BreastEC, OBIII
YWHAZtryptophan monooxygenase activation protein753488q23.1LungKB, SP, ECIIICell cycle, Pathogenic Escherichia coli infection - EHEC, Pathogenic Escherichia coli infection - EPEC
YWHAZtryptophan monooxygenase activation protein753488q23.1BladderSPIIICell cycle, Pathogenic Escherichia coli infection - EHEC, Pathogenic Escherichia coli infection - EPEC
TRIB1tribbles homolog 11022188q24.13Acute myeloid leukaemiaOEIII
MYCtranscription factor460988q24.21GastricECIIITMAPK signaling pathway, ErbB signaling pathway, Wnt signaling pathway, TGF-beta signaling pathway, Jak-STAT signaling pathway, Colorectal cancer, Endometrial cancer, Thyroid cancer, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer
MYCtranscription factor460988q24.21ProstateECIIITMAPK signaling pathway, ErbB signaling pathway, Wnt signaling pathway, TGF-beta signaling pathway, Jak-STAT signaling pathway, Colorectal cancer, Endometrial cancer, Thyroid cancer, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer
MYCtranscription factor460988q24.21MedulloblastomaECIIITMAPK signaling pathway, ErbB signaling pathway, Wnt signaling pathway, TGF-beta signaling pathway, Jak-STAT signaling pathway, Colorectal cancer, Endometrial cancer, Thyroid cancer, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer
MYCtranscription factor460988q24.21BreastDC, EC, KB, OBIIITMAPK signaling pathway, ErbB signaling pathway, Wnt signaling pathway, TGF-beta signaling pathway, Jak-STAT signaling pathway, Colorectal cancer, Endometrial cancer, Thyroid cancer, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer
MYCtranscription factor460988q24.21ColorectalDC, EC, SPIIITMAPK signaling pathway, ErbB signaling pathway, Wnt signaling pathway, TGF-beta signaling pathway, Jak-STAT signaling pathway, Colorectal cancer, Endometrial cancer, Thyroid cancer, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer
MYCtranscription factor460988q24.21LungFMIIITMAPK signaling pathway, ErbB signaling pathway, Wnt signaling pathway, TGF-beta signaling pathway, Jak-STAT signaling pathway, Colorectal cancer, Endometrial cancer, Thyroid cancer, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer
CCND1cyclin D15951111q13LungEC, SPIIITCell cycle, p53 signaling pathway, Wnt signaling pathway, Focal adhesion, Jak-STAT signaling pathway, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer
CCND1cyclin D15951111q13BreastEC, SP, OB, MSIITCell cycle, p53 signaling pathway, Wnt signaling pathway, Focal adhesion, Jak-STAT signaling pathway, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer
CCND1cyclin D15951111q13Oral squamous cell carcinomaEC, SPIIITCell cycle, p53 signaling pathway, Wnt signaling pathway, Focal adhesion, Jak-STAT signaling pathway, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer
CCND1cyclin D15951111q13Malignant melanomaSPIIITCell cycle, p53 signaling pathway, Wnt signaling pathway, Focal adhesion, Jak-STAT signaling pathway, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer
YAP1Yes-associated protein 1104131111q13LiverKB, MS, SPII
FADDFas-associated via death domain87721111q13.3Laryngeal squamous cell carcinomaECIIIApoptosis, Toll-like receptor signaling pathway
EMSY/C11orf30chromosome 11 open reading frame 30569461111q13.5BreastDC, SPIII
EMSY/C11orf30chromosome 11 open reading frame 30569461111q13.5OvarianSPIII
PAK1p21 protein (Cdc42/Rac)-activated kinase 150581111q13-q14BreastDC, SPIIIMAPK signaling pathway, ErbB signaling pathway, Axon guidance, Focal adhesion, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Epithelial cell signaling in Helicobacter pylori infection, Renal cell carcinoma
cIAP1/BIRC2baculoviral IAP repeat-containing 23291111q22LiverKB, MS, SPIIUbiquitin mediated proteolysis, Apoptosis, Focal adhesion, Small cell lung cancer
KRASG-protein38451212p12.1Testicular germ cell tumourMXIIIMisMAPK signaling pathway, ErbB signaling pathway, Axon guidance, VEGF signaling pathway, Tight junction, Gap junction, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Long-term potentiation, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Melanogenesis, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Non-small cell lung cancer
CCND2cyclin D28941212p13GliomaSPIIITCell cycle, p53 signaling pathway, Wnt signaling pathway, Focal adhesion, Jak-STAT signaling pathway
YEATS4YEATS domain containing 480891212q13-q15SarcomaSPIII
CDK4cyclin-dependent kinase 410191212q14GliomaDC, SPIIIMisCell cycle, p53 signaling pathway, Tight junction, T cell receptor signaling pathway, Pancreatic cancer, Glioma, Melanoma, Bladder cancer, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer
CDK4cyclin-dependent kinase 410191212q14SarcomaSPIIIMisCell cycle, p53 signaling pathway, Tight junction, T cell receptor signaling pathway, Pancreatic cancer, Glioma, Melanoma, Bladder cancer, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer
CDK4cyclin-dependent kinase 410191212q14BreastMSIIIMisCell cycle, p53 signaling pathway, Tight junction, T cell receptor signaling pathway, Pancreatic cancer, Glioma, Melanoma, Bladder cancer, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer
CDK4cyclin-dependent kinase 410191212q14Malignant melanomaIM, SPIIIMisCell cycle, p53 signaling pathway, Tight junction, T cell receptor signaling pathway, Pancreatic cancer, Glioma, Melanoma, Bladder cancer, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer
MDM2p53 binding protein41931212q14.3-q15SarcomaEC, SP, DIIICell cycle, p53 signaling pathway, Ubiquitin mediated proteolysis, Glioma, Prostate cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia
MDM2p53 binding protein41931212q14.3-q15BreastDC, EC, SP, OB, KBIIICell cycle, p53 signaling pathway, Ubiquitin mediated proteolysis, Glioma, Prostate cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia
MDM2p53 binding protein41931212q14.3-q15GliomaSPIIICell cycle, p53 signaling pathway, Ubiquitin mediated proteolysis, Glioma, Prostate cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia
MDM2p53 binding protein41931212q14.3-q15NeuroblastomaKB, DI, SP, OEIIICell cycle, p53 signaling pathway, Ubiquitin mediated proteolysis, Glioma, Prostate cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia
MDM2p53 binding protein41931212q14.3-q15LungSPIIICell cycle, p53 signaling pathway, Ubiquitin mediated proteolysis, Glioma, Prostate cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia
MDM2p53 binding protein41931212q14.3-q15GliomaSPIIICell cycle, p53 signaling pathway, Endocytosis, Pathways in cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia
DYRK2tyrosine-phosphorylation regulated kinase84451212q15SarcomaSPIII
DYRK2tyrosine-phosphorylation regulated kinase84451212q15OesophagealSPIII
GPC5glypican 522621313q32RhabdomyosarcomaOBIII
BCL2L2BCL2-like 25991414q11.2-q12LungKB, OB, SPIII
PAX9paired box 950831414q12-q13LungKB, OBIII
TITF1/NKX2-1NK2 homeobox 170801414q13LungKBIII
NKX2-8NK2 homeobox 8262571414q13.3LungKB, OBII
PLA2G10phospholipase A2, group X83991616p13.1-p12BreastSPIIIGlycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism, alpha-Linolenic acid metabolism, MAPK signaling pathway, VEGF signaling pathway, Fc epsilon RI signaling pathway, Long-term depression, GnRH signaling pathway
OLC1/KIAA0174KIAA017497981616q22.3LungKB, OBIII
COPS3COP9 homolog subunit 385331717p11.2OsteosarcomaKB, SPIII
ERBB2EGFR homolog20641717q11.2-q12GastricDI, SPIIIMis, OErbB signaling pathway, Calcium signaling pathway, Focal adhesion, Adherens junction, Pancreatic cancer, Endometrial cancer, Prostate cancer, Bladder cancer, Non-small cell lung cancer
ERBB2EGFR homolog20641717q11.2-q12OesophagealSPIIIMis, OErbB signaling pathway, Calcium signaling pathway, Focal adhesion, Adherens junction, Pancreatic cancer, Endometrial cancer, Prostate cancer, Bladder cancer, Non-small cell lung cancer
ERBB2EGFR homolog20641717q11.2-q12Oral squamous cell carcinomaSPIIIMis, OErbB signaling pathway, Calcium signaling pathway, Focal adhesion, Adherens junction, Pancreatic cancer, Endometrial cancer, Prostate cancer, Bladder cancer, Non-small cell lung cancer
ERBB2EGFR homolog20641717q11.2-q12BreastEC, SP, KB, OB, DI, DMIErbB signaling pathway, Calcium signaling pathway, Focal adhesion, Adherens junction, Pancreatic cancer, Endometrial cancer, Prostate cancer, Bladder cancer, Non-small cell lung cancer
ERBB2EGFR homolog20641717q11.2-q12OvarianEC, SPIIIErbB signaling pathway, Calcium signaling pathway, Focal adhesion, Adherens junction, Pancreatic cancer, Endometrial cancer, Prostate cancer, Bladder cancer, Non-small cell lung cancer
ERBB2EGFR homolog20641717q11.2-q12EndometrialEC, SPIIIErbB signaling pathway, Calcium signaling pathway, Focal adhesion, Adherens junction, Pancreatic cancer, Endometrial cancer, Prostate cancer, Bladder cancer, Non-small cell lung cancer
ERBB2EGFR homolog20641717q11.2-q12BladderEC, SPIIIErbB signaling pathway, Calcium signaling pathway, Focal adhesion, Adherens junction, Pancreatic cancer, Endometrial cancer, Prostate cancer, Bladder cancer, Non-small cell lung cancer
STARD3lipid transfer protein109481717q11-q12BreastKBIII
GRB7growth factor receptor-bound protein 728861717q12BreastSP, KBIII
CDC6cell division cycle 6 homolog9901717q21.3GastricSPIIICell cycle
RPS6KB1protein S6 kinase, polypeptide 161981717q23.1BreastEC, SPIIIErbB signaling pathway, mTOR signaling pathway, TGF-beta signaling pathway, Insulin signaling pathway, Acute myeloid leukemia
RPS6KB1protein S6 kinase, polypeptide 161981717q23.1OvarianKB, OBIIIErbB signaling pathway, mTOR signaling pathway, TGF-beta signaling pathway, Insulin signaling pathway, Acute myeloid leukemia
PPM1Dprotein phosphatase84931717q23.2BreastOB, OEIIIp53 signaling pathway
GATA6GATA binding protein 626271818q11.1-q11.2PancreatobillaryKBIII
CCNE1cyclin E18981919q12OesophagealECIIICell cycle, p53 signaling pathway, Prostate cancer, Small cell lung cancer
CCNE1cyclin E18981919q12BreastEC, KBIIICell cycle, p53 signaling pathway, Prostate cancer, Small cell lung cancer
AKT2serine kinase2081919q13.1-q13.2OvarianSP, KBIIIMAPK signaling pathway, ErbB signaling pathway, mTOR signaling pathway, Apoptosis, VEGF signaling pathway, Focal adhesion, Tight junction, Toll-like receptor signaling pathway, Jak-STAT signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Insulin signaling pathway, Adipocytokine signaling pathway, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer
IXL/MED29mediator complex subunit 29555881919q13.2PancreaticKBIII
AIB1/NCOA3nuclear receptor coactivator 382022020q12BreastEC, SP, IMII
YWHABtyrosine monooxygenase activation protein75292020q13.1BreastSPIII*Cell cycle
ZNF217zinc finger protein 21777642020q13.2BreastDC, OB, SPIIIc
AuroraA/AURKAaurora kinase A67902020q13.2-q13.3BreastDC, IM, OBIII
AuroraA/AURKAaurora kinase A67902020q13.2-q13.3OesophagealECIII
AuroraA/AURKAaurora kinase A67902020q13.2-q13.3BladderECIII
BRK/PTK6PTK6 protein tyrosine kinase 657532020q13.3BreastSP, OBIII
EEF1A2eukaryotic translation elongation factor19172020q13.3LungKB, ECIII
ARandrogen receptor367XXq11.2-q12ProstateDMIMisProstate cancer

Abbreviations

DI
Drug or antibody effect in cell lines containing amplification and overexpression but not in lines that lack amplification and overexpression
KB
Knockdown induces biological effect in cells containing amplification and overexpression but not in cells lacking amplification and overexpression
SP
Mutation or amplification and overexpression of other genes in the same pathway
FM
Other family members also amplified and overexpressed
IM
Inherited mutations predispose to the same cancer
KB
Knockdown or dominant negative causes biological effect
OB
Overexpression causes biological effect
MS
Substantial evidence from mouse studies
DI
Drug or antibody effective in vitro
DC
DNA copy number correlated with clinical outcome
OC
Expression level correlated with clinical outcome
MX
Mutation and amplification mutually exclusive
DM
Drug or antibody effective in man
OE
Other evidence (see download for further details)
Mis
Misssense mutation
T
Translocation
O
Other